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3CPET: finding co-factor complexes from ChIA-PET data using a hierarchical Dirichlet process
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DOI：10.1186/s13059-015-0851-6.png)
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摘要
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Various efforts have been made to elucidate the cooperating proteins involved in maintaining chromatin interactions; however, many are still unknown. Here, we present 3CPET, a tool based on a non-parametric Bayesian approach, to infer the set of the most probable protein complexes involved in maintaining chromatin interactions and the regions that they may control, making it a valuable downstream analysis tool in chromatin conformation studies. 3CPET does so by combining data from ChIA-PET, transcription factor binding sites, and protein interactions. 3CPET results show biologically significant and accurate predictions when validated against experimental and simulation data.
Keyword:
ChIA-PET
Chromatin interactions
Co-factors
Hierarchical Dirichlet process
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