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3D-DART: a DNA structure modelling server
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DOI：10.1093/nar/gkp287.png)
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摘要
En 中文
There is a growing interest in structural studies of DNA by both experimental and computational approaches. Often, 3D-structural models of DNA are required, for instance, to serve as templates for homology modeling, as starting structures for macro-molecular docking or as scaffold for NMR structure calculations. The conformational adaptability of DNA when binding to a protein is often an important factor and at the same time a limitation in such studies. As a response to the demand for 3D-structural models reflecting the intrinsic plasticity of DNA we present the 3D-DART server (3DNA-Driven DNA Analysis and Rebuilding Tool). The server provides an easy interface to a powerful collection of tools for the generation of DNA-structural models in custom conformations. The computational engine beyond the server makes use of the 3DNA software suite together with a collection of home-written python scripts. The server is freely available at http://haddock.chem.uu.nl/dna without any login requirement.
Keyword:
NUCLEIC-ACID STRUCTURES
HADDOCK
INFORMATION
TOOL
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期刊
IF:
13.1
论文数:
3.6W
被引数:
29.0W
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Information-driven protein-DNA docking using HADDOCK: it is a matter of flexibility.png)
NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
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