.png){kind=icon}
返回
A basic model for cell cholesterol homeostasis
.png){kind=icon}
OA
AI
DOI：10.1111/tra.12816.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Cells manage their cholesterol by negative feedback using a battery of sterol-responsive proteins. How these activities are coordinated so as to specify the abundance and distribution of the sterol is unclear. We present a simple mathematical model that addresses this question. It assumes that almost all of the cholesterol is associated with phospholipids in stoichiometric complexes. A small fraction of the sterol is uncomplexed and thermodynamically active. It equilibrates among the organelles, setting their sterol level according to the affinity of their phospholipids. The activity of the homeostatic proteins in the cytoplasmic membranes is then set by their fractional saturation with uncomplexed cholesterol in competition with the phospholipids. The high-affinity phospholipids in the plasma membrane (PM) are filled to near stoichiometric equivalence, giving it most of the cell sterol. Notably, the affinity of the phospholipids in the endomembranes (EMs) is lower by orders of magnitude than that of the phospholipids in the PM. Thus, the small amount of sterol in the EMs rests far below stoichiometric capacity. Simulations match a variety of experimental data. The model captures the essence of cell cholesterol homeostasis, makes coherent a diverse set of experimental findings, provides a surprising prediction and suggests new experiments.
Keyword:
cholesterol
complex
computation
homeostasis
model
phospholipid
plasma membrane
simulation
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
2.5
论文数:
2.4K
被引数:
5.8K
机构
引用论文
How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipidsOAAI
OAAI分享收藏Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape.png)
NATURE CHEMICAL BIOLOGYOAAI
NATURE CHEMICAL BIOLOGYIF13.7
OAAI分享收藏
查看更多内容