.png){kind=icon}
返回
A Cell-type-resolved Liver Proteome
.png){kind=icon}
OA
AI
DOI：10.1074/mcp.M116.060145.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Parenchymatous organs consist of multiple cell types, primarily defined as parenchymal cells (PCs) and non-parenchymal cells (NPCs). The cellular characteristics of these organs are not well understood. Proteomic studies facilitate the resolution of the molecular details of different cell types in organs. These studies have significantly extended our knowledge about organogenesis and organ cellular composition. Here, we present an atlas of the cell-type-resolved liver proteome. In-depth proteomics identified 6000 to 8000 gene products (GPs) for each cell type and a total of 10,075 GPs for four cell types. This data set revealed features of the cellular composition of the liver: (1) hepatocytes (PCs) express the least GPs, have a unique but highly homogenous proteome pattern, and execute fundamental liver functions; (2) the division of labor among PCs and NPCs follows a model in which PCs make the main components of pathways, but NPCs trigger the pathways; and (3) crosstalk among NPCs and PCs maintains the PC phenotype. This study presents the liver proteome at cell resolution, serving as a research model for dissecting the cell type constitution and organ features at the molecular level.
Keyword:
KUPFFER CELLS
QUANTIFICATION
IDENTIFICATION
BIOLOGY
DRAFT
AGE
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
M
IF:
5.5
论文数:
4.8K
被引数:
1.7W
机构
引用论文
.png){kind=icon}
An in-situ spectroscopic study of the anodic oxide film on a cobalt electrode at pH 4–14 by potential-modulated reflectance通过电位调制反射率对pH 4-14的钴电极上的阳极氧化膜进行原位光谱研究
PREAI
分享收藏
分享收藏
查看更多内容