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A chemically mediated artificial neuron
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DOI：10.1038/s41928-022-00803-0.png)
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Brain-machine interfaces typically rely on electrophysiological signals to interpret and transmit neurological information. In biological systems, however, neurotransmitters are chemical-based interneuron messengers. This mismatch can potentially lead to incorrect interpretation of the transmitted neuron information. Here we report a chemically mediated artificial neuron that can receive and release the neurotransmitter dopamine. The artificial neuron detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release through a heat-responsive hydrogel. The system responds to dopamine exocytosis from rat pheochromocytoma cells and also releases dopamine to activate pheochromocytoma cells, forming a chemical communication loop similar to interneurons. To illustrate the potential of this approach, we show that the artificial neuron can trigger the controllable movement of a mouse leg and robotic hand. An artificial neuron that detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release via a heat-responsive hydrogel, can be used to trigger the controllable movement of a mouse leg and robotic hand.
Keyword:
DOPAMINE SYSTEM
NEUROTRANSMITTERS
BIOELECTRONICS
BIOSENSORS
FUTURE
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40.9
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1.7K
被引数:
2.1W
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