A complex systems perspective on psychedelic brain action

doi:10.1016/j.tics.2023.01.003

2023-05-01

PRE

DOI：10.1016/j.tics.2023.01.003

原文链接

原文求助

摘要

En 中文

Recent findings suggesting the potential transdiagnostic efficacy of psychedelic -assisted therapy have fostered the need to deepen our understanding of psyche-delic brain action. Functional neuroimaging investigations have found that psychedelics reduce the functional segregation of large-scale brain networks. However, beyond this general trend, findings have been largely inconsistent. We argue here that a perspective based on complexity science that foregrounds the distributed, interactional, and dynamic nature of brain function may render these inconsistencies intelligible. We propose that psychedelics induce a mode of brain function that is more dynamically flexible, diverse, integrated, and tuned for information sharing, consistent with greater criticality. This 'meta' perspective has the potential to unify past findings and guide intuitions toward compelling mechanistic models.

Keyword:

NEURONAL AVALANCHES

PREFRONTAL CORTEX

5-HT2A RECEPTORS

NETWORK

CONNECTIVITY

CRITICALITY

ACTIVATION

PSILOCYBIN

SEROTONIN

STATE

期刊

Trends in Cognitive Sciences

IF:

17.2

论文数:

3.6K

被引数:

3.5W

机构

University of Sussex

学者数:

9.2K

论文数: 9.3K

被引数: 27

university of london

学者数:

21.5W

论文数: 19.7W

被引数: 305

McGill University

学者数:

5.5W

论文数: 4.9W

被引数: 7.0W

查看更多机构

引用论文

Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience Psilocybin诱导的脑网络完整性和分离的变化与血浆psilocyin水平和迷幻经验相关

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2021-09-01

OAAI

Madsen, Martin K.; Stenbaek, Dea S.; Arvidsson, Albin; Armand, Sophia; Marstrand-Joergensen, Maja R.; Johansen, Sys S.; Linnet, Kristian; Ozenne, Brice; Knudsen, Gitte M.; Fisher, Patrick M.

IF0

PREAI

Early detection of memory deficits and memory improvement with vaccinia virus complement control protein in an Alzheimer's disease model

Behavioural Brain Research

IF0

2008-10-01

PREAI

Nirvana S. Pillay; Laurie A. Kellaway; Girish J. Kotwal

Speciation analysis of organolead compounds in Greenland snow at the femtogram-per-gram level by capillary gas chromatography/atomic emission spectrometry

Analytical Chemistry

IF0

2002-05-01

PREAI

Ryszard. Lobinski; Claude F. Boutron; Jean Pierre. Candelone; Sungmin. Hong; Joanna. Szpunar-Lobinska; Freddy C. Adams

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor LSD诱导的意识状态改变中整体和丘脑脑连接的变化可归因于5-HT2A受体

ELIFE

IF0

2018-10-25

257

OAAI

Preller, Katrin H.; Burt, Joshua B.; Ji, Jie Lisa; Schleifer, Charles H.; Adkinson, Brendan D.; Stampfli, Philipp; Seifritz, Erich; Repovs, Grega; Krystal, John H.; Murray, John D.; Vollenweider, Franz X.; Anticevic, Alan

Increased global integration in the brain after psilocybin therapy for depression psilocybin治疗抑郁症后大脑的全球整合增加

NATURE MEDICINE

IF50

2022-04-11

212

OAAI

Daws, Richard E.; Timmermann, Christopher; Giribaldi, Bruna; Sexton, James D.; Wall, Matthew B.; Erritzoe, David; Roseman, Leor; Nutt, David; Carhart-Harris, Robin

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin 通过fMRI研究与psilocybin确定的迷幻状态的神经相关性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-01-23

723

OAAI

Carhart-Harris, Robin L.; Erritzoe, David; Williams, Tim; Stone, James M.; Reed, Laurence J.; Colasanti, Alessandro; Tyacke, Robin J.; Leech, Robert; Malizia, Andrea L.; Murphy, Kevin; Hobden, Peter; Evans, John; Feilding, Amanda; Wise, Richard G.; Nutt, David J.

REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics REBUS和无政府状态的大脑: 迈向迷幻药大脑行为的统一模型

PHARMACOLOGICAL REVIEWS

IF17.3

2019-07-01

478

OAAI

Carhart-Harris, R. L.; Friston, K. J.

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin 我，我自己，再见: 谷氨酸的区域变化和psilocybin的自我溶解经验

NEUROPSYCHOPHARMACOLOGY

IF7.1

2020-05-23

155

OAAI

Mason, N. L.; Kuypers, K. P. C.; Muller, F.; Reckweg, J.; Tse, D. H. Y.; Toennes, S. W.; Hutten, N. R. P. W.; Jansen, J. F. A.; Stiers, P.; Feilding, A.; Ramaekers, J. G.

Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

SCIENTIFIC REPORTS

IF3.9

2017-07-11

235

OAAI

Cabral, Joana; Vidaurre, Diego; Marques, Paulo; Magalhaes, Ricardo; Moreira, Pedro Silva; Soares, Jose Miguel; Deco, Gustavo; Sousa, Nuno; Kringelbach, Morten L.

查看更多内容