.png){kind=icon}
返回
A computational system for identifying operons based on RNA-seq data
.png){kind=icon}
OA
AI
DOI：10.1016/j.ymeth.2019.03.026.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
An operon is a set of neighboring genes in a genome that is transcribed as a single polycistronic message. Genes that are part of the same operon often have related functional roles or participate in the same metabolic pathways. The majority of all bacterial genes are co-transcribed with one or more other genes as part of a multi-gene operon. Thus, accurate identification of operons is important in understanding co-regulation of genes and their functional relationships. Here, we present a computational system that uses RNA-seq data to determine operons throughout a genome. The system takes the name of a genome and one or more files of RNA-seq data as input. Our method combines primary genomic sequence information with expression data from the RNA-seq files in a unified probabilistic model in order to identify operons. We assess our method's ability to accurately identify operons in a range of species through comparison to external databases of operons, both experimentally confirmed and computationally predicted, and through focused experiments that confirm new operons identified by our method.
Keyword:
Operon
Transcription
Polycistronic
Bacteria
Bioinformatics
RNA-seq
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.3
论文数:
4.8K
被引数:
2.4W
机构
引用论文
The sequence read archive: explosive growth of sequencing datasequence read archive: 测序数据的爆炸式增长.png)
NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏High accuracy operon prediction method based on STRING database scoresNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏OperonDB: a comprehensive database of predicted operons in microbial genomesNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Breathing air to save energy - new insights into the ecophysiological role of high-affinity [NiFe]-hydrogenase inStreptomyces avermitilisMICROBIOLOGYOPENOAAI
MICROBIOLOGYOPENIF4.6
OAAI分享收藏
查看更多内容