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A conserved function for pericentromeric satellite DNA
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DOI：10.7554/eLife.34122.png)
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A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi-AT-hook satellite DNA-binding proteins. Drosophila melanogaster D1 and mouse HMGA1, play an evolutionarily conserved role in bundling pericentromeric satellite DNA from heterologous chromosomes into 'chromocenters', a cytological association of pericentromeric heterochromatin. Defective chromocenter formation leads to micronuclei formation due to budding from the interphase nucleus, DNA damage and cell death. We propose that chromocenter and satellite DNA serve a fundamental role in encapsulating the full complement of the genome within a single nucleus, the universal characteristic of eukaryotic cells.
Keyword:
NUCLEAR-ENVELOPE RUPTURE
DROSOPHILA-MELANOGASTER
MAMMALIAN HETEROCHROMATIN
CELL-MIGRATION
CHROMOSOMES
PROTEINS
TRANSCRIPTION
GENOME
REPEAT
CHROMOTHRIPSIS
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0
论文数:
1.8W
被引数:
16
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GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion.png)
CURRENT BIOLOGYOAAI
CURRENT BIOLOGYIF7.5
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