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A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour-targeting function
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DOI：10.1111/bph.70564.png)
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Abstract
En 中文
Site-specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine- or cysteine-based conjugation methods generate heterogeneous products, while protein engineering approaches are resource-intensive. Affinity-guided covalent strategies using antibody binding peptides offer a chemical alternative for selective antibody functionalisation but are limited by challenges with incorporating reactive electrophiles into complex peptide ligands.
Keywords:
antibody bioconjugation
covalent chemical biology
covalent chemical probe
covalent modulator
covalent peptides
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