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A dynamical limit to evolutionary adaptation
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DOI：10.1073/pnas.2312845121.png)
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Natural selection makes evolutionary adaptation possible even if the overwhelming majority of new mutations are deleterious. However, in rapidly evolving populations where numerous linked mutations occur and segregate simultaneously, clonal interference and genetic hitchhiking can limit the efficiency of selection, allowing deleterious mutations to accumulate over time. This can in principle overwhelm the fitness increases provided by beneficial mutations, leading to an overall fitness decline. Here, we analyze the conditions under which evolution will tend to drive populations to higher versus lower fitness. Our analysis focuses on quantifying the boundary between these two regimes, as a function of parameters such as population size, mutation rates, and selection pressures. This boundary represents a state in which adaptation is precisely balanced by Muller's ratchet, and we show that it can be characterized by rapid molecular evolution without any net fitness change. Finally, we consider the implications of global fitness-mediated epistasis and find that under some circumstances, this can drive populations toward the boundary state, which can thus represent a long-term evolutionary attractor.
Keyword:
rapid evolution
evolutionary attractor
Muller's ratchet
fitness-mediated epistasis
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9.1
论文数:
10.8W
被引数:
73.5W
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Beneficial mutation-selection balance and the effect of linkage on positive selection有益的突变选择平衡和连锁对正选择的影响.png)
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