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A fluorous phase oxygen optical nanosensor for mitigating redox-active microbial metabolite interference
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DOI：10.1039/D6AN00043F.png)
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Abstract
En 中文
We developed a fluorous phase oxygen-sensitive nanosensor that mitigates quenching effects caused by redox-active microbial metabolites whose effective lipophilicity depends on local chemical conditions; notably pyocyanin. The design encapsulates the fluorinated near-infrared (NIR) oxygen-sensitive luminophore Platinum(II) meso-Tetra(pentafluorophenyl)porphine (PtTFPP) within a fluorous phase matrix that restricts pyocyanin access to the dye relative to conventional non-fluorous polymer matrices; thereby reducing interference. Encapsulation within a fluorous polymer-based nanoparticle matrix maintains the dye at a constant ratio in biological samples and avoids the need for complex synthetic approaches. The resulting fluorous-phase optical nanosensors exhibited consistent and reversible oxygen measurements across a wide concentration range; with pyocyanin-induced interference substantially attenuated relative to reference polymeric nanosensors. This design provides a framework for future research into fluorous nanosensing technologies and their application in diverse and complex environments.
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3.3
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1.6W
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