.png){kind=icon}
返回
A Molecular Dual Pump
.png){kind=icon}
PRE
AI
DOI：10.1021/jacs.9b08927.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Artificial molecular machines (AMMs) built from mechanically interlocked molecules (MIMs) can use energy ratchets to control the unidirectional motion of their component parts. These energy ratchets are operated by the alteration of kinetic barriers and thermodynamic wells, which are, in turn, determined by the switching on and off of noncovalent interactions. Previously, we have developed artificial molecular pumps (AMPs) capable of pumping rings consecutively onto a collecting chain as part of a molecular dumbbell, leading to the formation of rotaxanes. Here, we report a molecular dual pump (MDP) consisting of two individual AMPs linked in a head-to-tail fashion, wherein a single ring is pumped, in a linear manner, on and off a dumbbell involving a [2]rotaxane intermediate by exploiting the redox properties of the two pumps. This MDP, defined by the finely tuned noncovalent interactions and fueled by either chemicals or electricity, utilizes an energy ratchet mechanism to capture a ring and subsequently release it back into solution. The unidirectional motion and the resulting controlled capture and release of the ring were followed by 1D and 2D H-1 NMR spectroscopy and supported by control experiments. This molecular dual pump may be considered to be a forerunner of AMMs that are capable of pumping rings across a membrane in a way similar to how bacteriorhodopsin transports protons from one side of a membrane to the other under the influence of light. Such extensive multicomponent AMMs can lead potentially to molecular transporting platforms with positional and directional control of cargo uptake and release when, and only when, instructed.
Keyword:
MACHINES
TRANSPORT
CHEMISTRY
CHANNELS
DRIVEN
ROTARY
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
机构
引用论文
分享收藏A stepwise Huisgen cycloaddition process: Copper(I)-catalyzed regioselective ligation of azides and terminal alkynes逐步的Huisgen环加成过程: 铜 (I) 催化的叠氮化物和末端炔烃的区域选择性连接
PREAI
分享收藏Flexible Polyester Screen‐printed Electrode Modified with Carbon Nanofibers for the Electrochemical Aptasensing of Cadmium (II)用碳纳米纤维修饰的柔性聚酯丝网印刷电极，用于镉 (II) 的电化学感应
PREAI
分享收藏Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer.png)
iScience
OAAI
iScienceIF0
OAAI分享收藏Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides固相上的肽三唑: [1,2，3]-三唑通过区域特异性铜 (I) 催化的末端炔烃与叠氮化物的1，3-偶极环加成反应
PREAI
分享收藏
查看更多内容