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A multifunctional injectable hydrogel co-delivering GDF6 and MnO2 nanozymes alleviates intervertebral disc degeneration by mitigating oxidative stress and promoting anabolic repair

delete2026-07-28
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PRE
AI
C
Chao Wei
Q
Qin Tang
Y
Yanlin Tan
Q
Qianshi Zhang
Q
Qimu Tang
F
Fubin Liu
W
Wenzhe Li
Y
Yuhao Zheng
X
Xiaobin Wang *
J
Jing Li
DOI：10.1016/j.freeradbiomed.2026.07.045delete
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Abstract

Abstract

En 中文
• An injectable Gel@MnO2/GDF6 hydrogel co-delivers GDF6 and MnO2 nanozymes • Gel@MnO2/GDF6 protects nucleus pulposus cells from oxidative stress, restores ECM, and activates Smad signaling. • Intra-discal injection of Gel@MnO2/GDF6 attenuates rat disc degeneration with good biocompatibility.

Journal

Free Radical Biology and Medicine cover
Free Radical Biology and Medicine
IF:
8.2
Papers:
2.1W
Citations:
5.4W

Organization

U
university of electronic science and technology of china
Scholars:
1.1W
Papers: 4.3K
Citations: 4
C
central south university
Scholars:
1.7W
Papers: 5.0K
Citations: 3
S
sichuan mental health center
Scholars:
60
Papers: 16
Citations: 0
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