A multiple-encrypted DNA device for secure communication

Junke Wang

doi:10.1126/sciadv.aef9101

2026-07-03

DOI：10.1126/sciadv.aef9101

原文链接

原文求助

摘要

En 中文

DNA密码学因其DNA分子的高存储容量、DNA计算的显著并行性以及DNA纳米结构的多样性已被探索用于数据加密。然而，在单个DNA折纸通信工作流程中集成多种加密协议仍具挑战性。在此，我们开发了一种DNA多层加密设备，用于集成多种加密算法以实现安全通信。该编码系统利用矩形DNA纳米结构的可寻址性，将空间图案转化为纳米-摩尔斯密码。在基于密码本的对称加密框架中，由纳米-摩尔斯密码图案编码的密文信息通过共享密钥传输。此外，矩形与管状DNA纳米结构之间的转换允许进行隐写术和构象门控验证，其密钥空间为2576。我们通过传输“JUNE6 INVASION NORMANDY”这一信息，在基于块的消息归一化模式下演示了多层安全通信，实现了机密性、完整性和真实性。该工作将DNA纳米技术从结构支架推进至可编程的信息处理平台，对智能分子系统具有启示意义。

期刊

Science Advances

IF:

12.5

论文数:

2.1W

被引数:

18.1W

机构

shanghai jiao tong university

学者数:

15.7W

论文数: 11.7W

被引数: 159

nanjing university of posts and telecommunications

学者数:

3.8K

论文数: 1.6K

被引数: 0

引用论文

Diverse and robust molecular algorithms using reprogrammable DNA self-assembly

Nature

IF0

2019-03-20

PREAI

Damien Woods; David Doty; Cameron Myhrvold; Joy Hui; Felix Zhou; Peng Yin; Erik Winfree

On Applying Molecular Computation to the Data Encryption Standard

Journal of Computational Biology

IF0

1999-01-01

OAAI

LEONARD M. ADLEMAN; PAUL W. K. ROTHEMUND; SAM ROWEIS; ERIK WINFREE

Biocomputing security system: Concatenated enzyme-based logic gates operating as a biomolecular keypad lock

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2008-03-06

230

PREAI

Strack, Guinevere; Ornatska, Maryna; Pita, Marcos; Katz, Evgeny

A Molecular Cryptosystem for Images by DNA Computing

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2012-02-03

PREAI

Shoshani, Sivan; Piran, Ron; Arava, Yoav; Keinan, Ehud

High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography 高速3D DNA PAINT与无监督聚类用于解析3D DNA折纸密码

Nature Communications

IF15.7

2025-12-13

OAAI

Gde Bimananda Mahardika Wisna; Daria Sukhareva; Jonathan Zhao; Prathamesh Chopade; Deeksha Satyabola; Michael Matthies; Subhajit Roy; Chao Wang; Petr Šulc; Hao Yan; Rizal F. Hariadi

Complex shapes self-assembled from single-stranded DNA tiles

Nature

IF0

2012-05-30

OAAI

Bryan Wei; Mingjie Dai; Peng Yin

InfoBiology by printed arrays of microorganism colonies for timed and on-demand release of messages

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2011-09-26

OAAI

Palacios, Manuel A.; Benito-Pena, Elena; Manesse, Mael; Mazzeo, Aaron D.; LaFratta, Christopher N.; Whitesides, George M.; Walt, David R.