.png){kind=icon}
返回
A Multiscale Model for Solute Diffusion in Hydrogels
.png){kind=icon}
OA
AI
DOI：10.1021/acs.macromol.9b00753.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The number of biomedical applications of hydrogels is increasing rapidly on account of their unique physical, structural, and mechanical properties. The utility of hydrogels as drug delivery systems or tissue engineering scaffolds critically depends on the control of diffusion of solutes through the hydrogel matrix. Predicting or even modeling this diffusion is challenging due to the complex structure of hydrogels. Currently, the diffusivity of solutes in hydrogels is typically modeled by one of three main theories proceeding from distinct diffusion mechanisms: (i) hydrodynamic, (ii) free volume, and (iii) obstruction theory. Yet, a comprehensive predictive model is lacking. Thus, time and capital-intensive trial-and-error procedures are used to test the viability of hydrogel applications. In this work, we have developed a model for the diffusivity of solutes in hydrogels combining the three main theoretical frameworks, which we call the multiscale diffusion model (MSDM). We verified the MSDM by analyzing the diffusivity of dextran of different sizes in a series of poly(ethylene glycol) (PEG) hydrogels with distinct mesh sizes. We measured the subnanoscopic free volume by positron annihilation lifetime spectroscopy (PALS) to characterize the physical hierarchy of these materials. In addition, we performed a meta-analysis of literature data from previous studies on the diffusion of solutes in hydrogels. The model presented outperforms traditional models in predicting solute diffusivity in hydrogels and provides a practical approach to predicting the transport properties of solutes such as drugs through hydrogels used in many biomedical applications.
Keyword:
POLY(ETHYLENE GLYCOL)
DRUG-DELIVERY
FREE-VOLUME
TRANSPORT
WATER
GELS
MACROMOLECULES
ANNIHILATION
SUSPENSIONS
MEMBRANES
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
5.2
论文数:
3.7W
被引数:
9.4W
机构
引用论文
分享收藏Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering用于组织工程的聚乙二醇水凝胶的生物活性改性.png)
BIOMATERIALSOAAI
BIOMATERIALSIF12.9
OAAI分享收藏Hydrogels in controlled release formulations: Network design and mathematical modeling控释制剂中的水凝胶: 网络设计和数学建模
PREAI
分享收藏Cholesterol-Ceramide Interactions in Phospholipid and Sphingolipid Bilayers As Observed by Positron Annihilation Lifetime Spectroscopy and Molecular Dynamics SimulationsLANGMUIR
LANGMUIRIF3.9
PREAI
分享收藏
查看更多内容