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A Multiverse Analysis of the Logical Memory Test and Plasma Biomarkers of Alzheimer’s Disease
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DOI：10.1016/j.cortex.2026.06.005.png)
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Abstract
En 中文
Alzheimer’s disease (AD) detection with blood-based biomarkers promises to revolutionise dementia diagnosis. However, blood testing is still a challenge in remote settings. Cognitive testing that is sensitive to plasma biomarker levels can be a useful proxy. A common test for dementia assessment is the logical memory test (LMT) – where a story is read out loud to the individual and then freely recalled. Alongside standard metrics, item-based metrics, such as recall of proper names and serial positions, are effective at detecting AD-related pathology. We set out to compare a range of LMT metrics against plasma AD biomarkers, and examine differences between men and women.
Keywords:
Logical memory test
plasma biomarkers
p-tau217
Alzheimer’s disease
sex differences
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