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A MYCN–GAL–SREBP1 Lipogenic Axis Drives Proliferation in Silent Corticotroph Adenomas

delete2026-06-23
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PRE
AI
C
Changxi Han
J
Junchen Wu
J
Jing Xie
J
Jun Li
Z
Zongze He
B
Bo Zhang
Y
Yihan Dong
Q
Qiuyue Fang
J
Jingwei Ye
Z
Zhuoyi Tang
C
Can Xu
J
Jing Yang
Y
Yangyang Wang
M
Mingjun Gao
J
Jin Zhang
H
Huan Xiong
Z
Zhe Bao Wu
R
Ruxiang Xu
S
Shaojian Lin *
DOI：10.1093/neuonc/noag141delete
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Abstract

Abstract

En 中文
Silent corticotroph adenomas (SCAs) are an aggressive pituitary neuroendocrine tumor (PitNET) subtype lacking effective medical therapies and showing a high rate of recurrence. The molecular mechanisms driving their proliferation remain poorly understood. Although metabolic reprogramming is a hallmark of cancer, neither lipid metabolism nor its regulatory pathways have been systematically investigated in SCAs.

Journal

N
Neuro-Oncology
IF:
13.4
Papers:
1.2W
Citations:
2.5W

Organization

U
university of electronic science and technology of china
Scholars:
1.1W
Papers: 4.3K
Citations: 4
T
The First Affiliated Hospital of Wenzhou Medical University
Scholars:
1.4K
Papers: 429
Citations: 1
S
shanghai jiao tong university school of medicine
Scholars:
1.1K
Papers: 277
Citations: 0
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