A redox homeostasis-modulating protective strategy for pancreatitis: Selenoprotein W modulates Keap1/Nrf2/PPARγ/NF-κB interaction to alleviate pancreatic injury

Y Zhang

doi:10.1016/j.freeradbiomed.2026.07.039

A redox homeostasis-modulating protective strategy for pancreatitis: Selenoprotein W modulates Keap1/Nrf2/PPARγ/NF-κB interaction to alleviate pancreatic injury

2026-07-23

0

PRE

AI

Y

Y Zhang

J

Jiawei Wu

Y

Yihan Chang

M

Man Qian

Y

Yao Xue

Y

Yudi Zhang

L

Lidong Chao

X

Xuejiao Gao *

DOI：10.1016/j.freeradbiomed.2026.07.039

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Abstract

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• Selenium through selenoprotein W alleviates HFG-induced pancreatic injury. • Selenoprotein W reduces HFG-induced ROS release. • Selenoprotein W protects pancreatic islet β cells via the Keap1/Nrf2/PPARγ/NF-κB.

A redox homeostasis-modulating protective strategy for pancreatitis: Selenoprotein W modulates Keap1/Nrf2/PPARγ/NF-κB interaction to alleviate pancreatic injury

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