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A rigid body framework for multicellular modeling
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DOI：10.1038/s43588-021-00154-4.png)
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Off-lattice models are a well-established approach in multicellular modeling, where cells are represented as points that are free to move in space. The representation of cells as point objects is useful in a wide range of settings, particularly when large populations are involved; however, a purely point-based representation is not naturally equipped to deal with objects that have length, such as cell boundaries or external membranes. Here we introduce an off-lattice modeling framework that exploits rigid body mechanics to represent objects using a collection of conjoined one-dimensional edges in a viscosity-dominated system. This framework can be used to represent cells as free moving polygons, to allow epithelial layers to smoothly interact with themselves, to model rod-shaped cells such as bacteria and to robustly represent membranes. We demonstrate that this approach offers solutions to the problems that limit the scope of current off-lattice multicellular models.
Keyword:
IN-SITU DCIS
INTESTINAL CRYPT
CELL
MECHANICS
GROWTH
ORGANIZATION
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18.3
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3.1K
被引数:
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plos biology
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