A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response

Emerson L. Grey

doi:10.1016/j.jconrel.2026.115225

A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response

2026-07-31

0

PRE

AI

E

Emerson L. Grey

B

Brittany J. Thompson

C

Chun‐Yi Chang

D

Daniel Estrin

S

Stephanie J. Bryant *

DOI：10.1016/j.jconrel.2026.115225

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Abstract

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• A new stimuli-responsive hydrogel is developed to target inflammatory macrophages. • Release of MyD88 inhibitor is controlled by an MMP-12 linker. • The released inhibitor product is taken up by macrophages and retains its bioactivity. • The therapeutic hydrogel inhibits the foreign body response in a mouse model.

A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response

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