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A structural and functional subdivision in central orbitofrontal cortex
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DOI：10.1038/s41467-022-31273-9.png)
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摘要
En 中文
Economic choice requires many cognitive subprocesses, including stimulus detection, valuation, motor output, and outcome monitoring; many of these subprocesses are associated with the central orbitofrontal cortex (cOFC). Prior work has largely assumed that the cOFC is a single region with a single function. Here, we challenge that unified view with convergent anatomical and physiological results from rhesus macaques. Anatomically, we show that the cOFC can be subdivided according to its much stronger (medial) or weaker (lateral) bidirectional anatomical connectivity with the posterior cingulate cortex (PCC). We call these subregions cOFCm and cOFCl, respectively. These two subregions have notable functional differences. Specifically, cOFCm shows enhanced functional connectivity with PCC, as indicated by both spike-field coherence and mutual information. The cOFCm-PCC circuit, but not the cOFCl-PCC circuit, shows signatures of relaying choice signals from a non-spatial comparison framework to a spatially framed organization and shows a putative bidirectional mutually excitatory pattern. A portion of the orbitofrontal cortex can be subdivided by its connectivity with the posterior cingulate cortex. This connectivity-based parcellation shows differences in functional connectivity and economic choice signals.
Keyword:
POSTERIOR CINGULATE CORTEX
PREFRONTAL CORTEX
ECONOMIC CHOICE
CORTICAL CONNECTIONS
PARIETAL CORTEX
FRONTAL-CORTEX
RHESUS-MONKEY
COGNITIVE MAP
VALUE SIGNALS
NEURONS
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期刊
IF:
15.7
论文数:
9.4W
被引数:
91.2W
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