A tutorial on biomedical process control

doi:10.1016/j.jprocont.2007.01.012

A tutorial on biomedical process control

2007-08-01

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DOI：10.1016/j.jprocont.2007.01.012

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This paper presents a tutorial on five typical applications within the area of biomedical process control. The specific applications discussed include: control of insulin administration for treating diabetes mellitus, dynamic modeling for anti-cancer chemotherapy regimen design, modeling and control of drug infusion in critical care, structured treatment interruptions: a control mathematical approach to AIDS protocol design, and dynamic modeling and control of the anticoagulant drug heparin. The objective of the tutorial is to illustrate the rich and important set of problems within the biomedical area that process control engineers can contribute to solving. Solution to these problems can have a significant medical as well as economic impact.

Keyword:

model based control

dynamic modeling

optimization

constraints

parameter estimation

drug delivery

pharmacokinetics

anticoagulation

chemotherapy

diabetes

HIV/AIDS therapy

critical care

A tutorial on biomedical process control

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