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A universal biosensing platform based on optical micro-ring resonators
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DOI：10.1016/j.bios.2007.09.007.png)
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The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. (C) 2007 Elsevier B.V. All rights reserved.
Keyword:
micro-ring resonators
biosensor
label-free quantitative detection
optical resonators
whole cell detection
antibody
antigen
nucleic acid
bacteria
IgG
IgM
期刊
IF:
10.5
论文数:
1.8W
被引数:
7.7W
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