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A zinc deficiency leads to non-inflammatory pruritus by modifying opioid receptor signaling
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DOI：10.1016/j.jdermsci.2026.05.006.png)
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Abstract
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• Patients with non-inflammatory pruritus (NIP) showed zinc deficiency (ZD), which was more pronounced than those with inflammatory pruritus (IP). • Zinc supplementation improved NIP symptom along with normalization of zinc levels. • Compared to control mice, ZD model mice showed an increased sensitivity to morphine-mediated pruritus, which were reversed by kappa opioid receptor agonist, nalfurafine, pretreatment. • The results implicated that zinc is critically related to pruritus through modulation of opioid receptor signaling.
Keywords:
zinc deficiency
non-inflammatory pruritus
opioid receptor signaling
nalfurafine
morphine-mediated pruritus
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