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ABC50 mutants modify translation start codon selection

delete2015-04-02
delete22
PRE
AI
J
Joanna D. Stewart
J
Joanne L. Cowan
L
Lisa Perry
M
Mark J. Coldwell *
C
Christopher G. Proud
DOI：10.1042/BJ20141453delete
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摘要

摘要

En 中文
ATP结合盒50 (ABC50; 也称为ABCF1) 与真核起始因子2 (eIF2) 结合，并且是有效翻译起始所必需的。该过程的必要步骤是准确识别和选择起始密码子。广泛接受的是，eIF1、eIF1A和eIF5的存在和移动是调节起始位点选择的严格性的关键因素，这通常需要在适当的序列背景下的AUG密码子。在本研究中，我们显示不能水解ATP的ABC50突变体的表达降低了一般翻译，并放松了对在翻译起始位点使用非AUG密码子的歧视。这些突变体似乎没有改变关键起始因子与40s亚基的关联。起始位点选择的严格性可以通过eIF1的过表达来恢复，这与该因子在增强严格性中的作用一致。本研究表明，干扰ABC50的功能会影响起始密码子选择的准确性。
Keyword:
translation initiation
eIF2
ABCF1
start codon
accuracy
initiation factor
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期刊

Biochemical Journal 封面图
Biochemical Journal
IF:
4.3
论文数:
1.5W
被引数:
3.8W

机构

U
university of southampton
学者数:
3.3W
论文数: 3.2W
被引数: 52
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