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Accelerating Multiparametric Quantitative MRI Using Self-Supervised Scan-Specific Implicit Neural Representation With Model Reinforcement
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DOI：10.1002/mrm.70227.png)
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Purpose To develop a self-supervised scan-specific deep learning framework for reconstructing accelerated multiparametric quantitative MRI (qMRI).Methods We propose REFINE-MORE (REference-Free Implicit NEural representation with MOdel REinforcement), combining an implicit neural representation (INR) architecture with a model reinforcement module that incorporates MR physics constraints. The INR component enables informative learning of spatiotemporal correlations to initialize multiparametric quantitative maps, which are then further refined through an unrolled optimization scheme enforcing data consistency. To improve computational efficiency, REFINE-MORE integrates a low-rank adaptation strategy that promotes rapid model convergence. We evaluated REFINE-MORE on accelerated multiparametric quantitative magnetization transfer imaging for simultaneous estimation of free water spin-lattice relaxation, tissue macromolecular proton fraction, and magnetization exchange rate, using both phantom and in vivo brain data.Results Under 4x and 5x accelerations on in vivo data, REFINE-MORE achieved superior reconstruction quality, demonstrating the lowest normalized root-mean-square error and highest structural similarity index compared to baseline methods and other state-of-the-art model-based and deep learning approaches. Phantom experiments further showed strong agreement with reference values, underscoring the robustness and generalizability of the proposed framework. Additionally, the model adaptation strategy improved reconstruction efficiency by approximately fivefold.Conclusion REFINE-MORE enables accurate and efficient scan-specific multiparametric qMRI reconstruction, providing a flexible solution for high-dimensional, accelerated qMRI applications.
Keyword:
implicit neural representation
model reinforcement
multiparametric quantitative MRI
quantitative magnetization transfer
self-supervised deep learning
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被引数:
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