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Achieving regioselective materials binding using multidomain peptides

delete2022-01-01
delete2
PRE
AI
R
Ruitao Jin
N
Nermina Brljak
T
Tiffany R. Walsh *
M
Marc R. Knecht *
DOI:10.1039/d2nr03169hdelete
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摘要

摘要

En 中文
The ability to integrate two disparate materials-binding domains into a single ligand to achieve regiospecific binding would be powerful to direct material assembly; however, this has proven challenging to achieve due to cross-materials binding. Accomplishing this goal might be achieved by harnessing the precision of biology to exploit the recognition between peptides and specific nanomaterials. Here, a designed bifunctional molecule termed Biomolecular Exfoliant and Assembly Motifs (BEAM) is introduced, featuring two different materials-binding peptide domains, one for graphene and one for hexagonal boron nitride (h-BN), at each end of the molecule, separated by a fatty acid spacer. The BEAM is demonstrated to bind strongly to both graphene and h-BN surfaces, and in each case the materials-binding peptide domain is shown to preferentially bind its target material. Critically, the two materials-binding domains exhibited limited cross-domain interaction. The BEAM design concept shows substantial potential to eventually guide self-organization of a range of materials in aqueous media.
Keyword:
BORON-NITRIDE
GOLD
NANOPARTICLES
BIONANOCOMBINATORICS
ORIENTATION
SURFACES
AU

期刊

Nanoscale 封面图
Nanoscale
IF:
5.1
论文数:
3.0W
被引数:
11.6W

机构

U
university of miami
学者数:
3.4W
论文数: 2.6W
被引数: 32
D
Deakin University
学者数:
2.0W
论文数: 2.1W
被引数: 2.8W
引用论文

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