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Activity-dependent synaptic competition and dendrite pruning in developing mitral cells
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DOI：10.3389/fncir.2025.1541926.png)
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During the early postnatal period, neurons in sensory circuits dynamically remodel their connectivity to acquire discrete receptive fields. Neuronal activity is thought to play a central role in circuit remodeling during this period: Neuronal activity stabilizes some synaptic connections while eliminating others. Synaptic competition plays a central role in the binary choice between stabilization and elimination. While activity-dependent punishment signals propagating from winner to loser synapses have been hypothesized to drive synapse elimination, their exact nature has remained elusive. In this review, I summarize recent studies in mouse mitral cells that explain how only one dendrite is stabilized while others are eliminated, based on early postnatal spontaneous activity in the olfactory bulb. I discuss how the hypothetical punishment signals act on loser but not winner dendrites to establish only one primary dendrite per mitral cell, the anatomical basis for the odorant receptor-specific parallel information processing in the olfactory bulb.
Keyword:
synapse elimination
synaptic competition
dendrite pruning
mitral cell
olfactory bulb
spontaneous activity
NMDA receptor
RhoA
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Spontaneous activity in whisker-innervating region of neonatal mouse trigeminal ganglion.png)
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