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Acute elevation of anandamide and 2-AG levels modulates defensive behavior in a sex- and strain-dependent manner in an animal model of attention-deficit/hyperactivity disorder

delete2026-05-04
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D
Daniel Bussinger de Souza Penna *
S
Samara Gumiéro Costa
G
Gabriel Ferreira dos Santos
P
Paula Moreno Peixoto
L
Lia Michaeli dos Reis Laport
A
Amanda Fialho Ferreira
A
Alexandre dos Santos Rodrigues
R
Rafael Brito
K
Karin da Costa Calaza
P
Pablo Pandolfo
DOI：10.1016/j.pbb.2026.174200delete
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Abstract

Abstract

En 中文
• Spontaneously hypertensive rats display impairment in defensive repertoire. • Inhibition of MAGL and FAAH produces strain- and sex-dependent defensive effects. • The ADHD model shows sex and strain differences in CB1R, CB2R, FAAH and MAGL levels.
Keywords:
Executive functions
Endocannabinoids
Risk behavior
Anxiety
Behavioral tasks
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Journal

Pharmacology Biochemistry and Behavior cover
Pharmacology Biochemistry and Behavior
IF:
2.5
Papers:
7.6K
Citations:
9.9K

Organization

F
fluminense federal university
Scholars:
352
Papers: 151
Citations: 0
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