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Acute food deprivation attenuates methamphetamine-induced locomotor sensitization and decreases glucose, insulin, and Akt levels in rats
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DOI：10.1016/j.pbb.2026.174197.png)
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Abstract
En 中文
• Methamphetamine (METH)-induced dopaminergic sensitization is influenced by metabolic state. • Insulin signaling modulates DAT activity and psychostimulant effects. • Acute food deprivation reduces insulin levels and decreases METH-induced locomotor sensitization. • Food deprivation lowers glucose and insulin levels and reduces Akt phosphorylation.
Keywords:
Methamphetamine
Insulin signaling
Dopaminergic sensitization
Food deprivation
Akt phosphorylation
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