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摘要
En 中文
Acute Ischemic Stroke Treatment for patients with acute ischemic stroke is guided by the time from the onset of stroke, the severity of neurologic deficit, and findings on neuroimaging. By convention, the time of stroke onset is established as the time that the patient was last known to be well (i.e., in a normal or baseline state, as confirmed by medical history). Intravenous thrombolysis with alteplase (a recombinant tissue plasminogen activator) improves outcomes in selected patients with acute ischemic stroke when administered within 4.5 hours after onset. Later treatment may improve outcomes in selected patients, with the treatment window extended to 9 hours from onset. Intraarterial catheter-based mechanical thrombectomy of occluded large intracranial arteries improves outcomes in selected patients with acute ischemic stroke when performed up to 24 hours after onset. The benefit of alteplase and mechanical thrombectomy is time-dependent, so assessment and treatment should be instituted rapidly. In selected patients with mild acute ischemic stroke who do not qualify for intravenous thrombolysis or mechanical thrombectomy, dual antiplatelet therapy with clopidogrel and aspirin when administered within 24 hours after onset and continuedfor 21 days lowers the risk of recurrent stroke. Treatment for patients with acute ischemic stroke is guided by the time from the onset of stroke, the severity of neurologic deficit, and findings on neuroimaging. Recommended treatments in selected patients include intravenous thrombolysis with alteplase and mechanical thrombectomy.
Keyword:
ACUTE MINOR STROKE
ENDOVASCULAR THROMBECTOMY
MECHANICAL THROMBECTOMY
ASPIRIN
TRIAL
RELIABILITY
CLOPIDOGREL
GUIDELINES
SCALE
RISK
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期刊
IF:
78.5
论文数:
2.7W
被引数:
39.7W
机构
引用论文
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LANCET
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Extending thrombolysis to 4.5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data使用灌注成像将溶栓延长至4.5-9小时和唤醒卒中: 个体患者数据的系统评价和荟萃分析
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IF88.5
Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials改良Rankin量表的演变及其在未来卒中试验中的应用
STROKE
IF8.9
Indications for early aspirin use in acute ischemic stroke - A combined analysis of 40 000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial
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