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Adding New Chemistries to the Genetic Code
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DOI：10.1146/annurev.biochem.052308.105824.png)
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The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of Escherichia coli, yeast, and mammalian cells. These UAAs represent a wide range of structures and functions not found in the canonical 20 amino acids and thus provide new opportunities to generate proteins with enhanced or novel properties and probes of protein structure and function.
Keyword:
aminoacyl-tRNA synthetase
protein engineering
protein evolution
translation
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20.5
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2.2K
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分享收藏Control of protein phosphorylation with a genetically encoded photocaged amino acid.png)
NATURE CHEMICAL BIOLOGY
NATURE CHEMICAL BIOLOGYIF13.7
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A non-natural amino acid for efficient incorporation into proteins as a sensitive fluorescent probe一种非天然氨基酸，可有效掺入蛋白质中作为灵敏的荧光探针FEBS LETTERS
FEBS LETTERSIF3
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