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Addressing missing context in regulatory variation across primate evolution
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2025-06-26
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DOI：10.1016/j.gde.2025.102374.png)
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摘要
En 中文
在灵长类动物中，与适应性性状变异相关的基因座通常位于非编码区域。理解将这类调控变异与适合度相关的表型相联系的机制仍然具有挑战性，但可以通过功能基因组数据来解决。然而，这类数据在非人类灵长类动物中很少大规模生成。即使生成时，通常也仅考虑了特定的组织、细胞类型、发育阶段和细胞环境，尽管越来越认识到适应性变异往往表现出依赖上下文的效果。在本综述中，我们（1）讨论依赖上下文的调控基因座为何可能特别有助于理解灵长类动物的适应性进化，（2）探讨绘制这类依赖上下文变异的挑战及新兴解决方案，以及（3）讨论这些数据可能解决的科学问题。填补这些空白将为进化过程、人类疾病和调控适应提供关键见解。
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引用论文
A map of human genome variation from population-scale sequencing来自人口规模测序的人类基因组变异图.png)
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ScienceIF0
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CELL STEM CELLIF20.4
2023-07-0138OAAILazaro, Jorge; Costanzo, Maria; Sanaki-Matsumiya, Marina; Girardot, Charles; Hayashi, Masafumi; Hayashi, Katsuhiko; Diecke, Sebastian; Hildebrandt, Thomas B.; Lazzari, Giovanna; Wu, Jun; Petkov, Stoyan; Behr, Ruediger; Trivedi, Vikas; Matsuda, Mitsuhiro; Ebisuya, Miki分享收藏
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