Adenovirus DNA Replication

Rob C. Hoeben

doi:10.1101/cshperspect.a013003

Adenovirus DNA Replication

2013-02-06

116

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AI

DOI：10.1101/cshperspect.a013003

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Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basic replication strategy of adenoviruses and the key proteins involved and will deal with the new developments since 2006. In addition, we will cover the development of antivirals that interfere with human adenovirus (HAdV) replication and the impact of HAdV on human disease.

Keyword:

STEM-CELL TRANSPLANTATION

EXONUCLEASE ACTIVE-SITE

PROTEIN-PRIMED INITIATION

SLIDING-BACK MECHANISM

EXO-III MOTIF

STRAND-DISPLACEMENT

TERMINAL PROTEIN

BINDING-PROTEIN

IN-VITRO

MUTATIONAL ANALYSIS

Adenovirus DNA Replication

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