.png){kind=icon}
返回
Adhesion-dependent cell mechanosensitivity
.png){kind=icon}
PRE
AI
DOI：10.1146/annurev.cellbio.19.111301.153011.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The conversion of physical signals, such as contractile forces or external mechanical perturbations, into chemical signaling events is a fundamental cellular process that occurs at cell-extracellular matrix contacts, known as focal adhesions. At these sites, transmembrane integrin receptors are associated via their cytoplasmic domains with the actin cytoskeleton. This interaction with actin is mediated by a submembrane plaque, consisting of numerous cytoskeletal and signaling molecules. Application of intrinsic or external forces to these structures dramatically affects their assembly and triggers adhesion-mediated signaling. In this review, we discuss the structure-function relationships of focal adhesions and the possible mode of action of the putative mechanosensor associated with them. We also discuss the general phenomenon of mechanosensitivity, and the approaches used to measure local forces at adhesion sites, the cytoskeleton-mediated regulation of local contractility, and the nature of the signaling networks that both affect contractility and are affected by it.
Keyword:
focal adhesions
ECM
cell contractility
microtubules
Rho
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
11.4
论文数:
716
被引数:
9.9K
机构
暂无机构信息
引用论文
Restricted Mean Survival Time: An Obligatory End Point for Time-to-Event Analysis in Cancer Trials?
PREAI
分享收藏分享收藏Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.png)
CURRENT BIOLOGY
OAAI
CURRENT BIOLOGYIF7.5
OAAI分享收藏Force generation by actin polymerization II: The elastic ratchet and tethered filamentsBIOPHYSICAL JOURNALOAAI
BIOPHYSICAL JOURNALIF3.1
OAAI分享收藏
查看更多内容