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Adipose TGFβ-asprosin memory promotes obesity relapse and offspring obesity susceptibility
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DOI:10.1016/j.celrep.2026.117809.png)
Abstract
En 中文
• TGF-β1 induces a persistent adipose transcriptional memory • Sustained asprosin elevation promotes obesity relapse after weight loss • Maternal TGF-β1 increases offspring susceptibility to diet-induced obesity • Blocking the TGF-β1-asprosin-Ptprd axis prevents relapse and offspring obesity
Keywords:
obesity
weight regain
developmental programming
epigenetic memory
asprosin
FBN1
TGF-β1
CP: metabolism
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