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Advances in modeling analysis for multi-parameter bioreactor process control

delete2025-01-14
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PRE
AI
L
Lin, Xin
李可 封面图
李可 (Ke Li)
C
Changzhe Wu
C
Cheng Zhang
G
Guanghao Zhang
X
Xiaolin Huo *
DOI：10.1007/s12257-024-00174-7delete
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摘要

摘要

En 中文
生物反应器系统的多参数复杂过程控制对细胞培养提出了紧迫的挑战。通过利用生物反应器建模，可以实现对每个参数对培养过程影响的模拟与分析，理解细胞培养过程中关键变量间的相关性，并建立多参数协同调控的框架。本文综述了多参数过程控制的模型实施方法，以及与生物工程、组织工程或肝细胞培养过程中涉及的生理过程、培养环境和生物反应器结构相关的数学模型的分析与优化技术。随后探讨了使用数字孪生的遗留障碍与潜力。鉴于此，该综述展望了生物反应器肝细胞体外培养系统及生物人工肝临床支持系统的过程优化与控制，旨在加深对肝细胞培养过程的理解，并满足生物人工肝疗法对肝细胞数量和质量的要求。
Keyword:
Bioreactor
Modeling
Process control
Parameter optimization
Bioartificial liver
Hepatocyte

期刊

Biotechnology and Bioprocess Engineering 封面图
Biotechnology and Bioprocess Engineering
IF:
3
论文数:
176
被引数:
3.2K

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