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Advances in the biological mechanism and application of manganese-based nanoformulations for enhanced immunotherapy
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DOI：10.1016/j.nantod.2022.101583.png)
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Abstract
En 中文
The combination of nanomaterial and immunotherapy has facilitated the effective use of the body's im-mune system to fight cancer, promising good biological safety and effectiveness. Manganese (Mn)-based nanoformulations have attracted increasing attention, providing a broad prospect in immunotherapy. This review focuses on the mechanisms of immunomodulation of Mn-based nanoformulation, including the activation of the cyclic GMP-AMP synthase-stimulator of interferon genes pathway, Nod-like receptor fa-mily pyrin domain containing protein 3 inflammasome, immunogenic cell death and regulation of the immunosuppressive tumour microenvironment. We further exemplified these mechanisms in cancer im-munotherapy, including vaccine adjuvants, drug delivery systems and their combination with immune checkpoint inhibitor therapies or with photodynamic/photothermal therapy. Finally, we discussed the obstacles in the clinical translation of Mn-based nanoformulations. We hope that this review may provide a new understanding of the biological mechanisms and applications of Mn-based nanoformulations in cancer immunotherapy to cope with the difficulties and challenges in their future development.(c) 2022 Elsevier Ltd. All rights reserved.
Keywords:
Manganese-based nanoformulations
Mechanisms of immunomodulation
Immunotherapy
Anti-tumour
Manganese-based nanoformulations
Mechanisms of immunomodulation
Immunotherapy
Anti-tumour
Journal
IF:
10.9
Papers:
3.0K
Citations:
2.1W