.png){kind=icon}
返回
Advancing Human Vaccine Development Using Humanized Mouse Models
.png){kind=icon}
OA
AI
DOI：10.3390/vaccines12091012.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The development of effective vaccines against infectious diseases remains a critical challenge in global health. Animal models play a crucial role in vaccine development by providing valuable insights into the efficacy, safety, and mechanisms of immune response induction, which guide the design and formulation of vaccines. However, traditional animal models often inadequately recapitulate human immune responses. Humanized mice (hu-mice) models with a functional human immune system have emerged as invaluable tools in bridging the translational gap between preclinical research and clinical trials for human vaccine development. This review summarizes commonly used hu-mice models and advances in optimizing them to improve human immune responses. We review the application of humanized mice for human vaccine development with a focus on HIV-1 vaccines. We also discuss the remaining challenges and improvements needed for the currently available hu-mice models to better facilitate the development and testing of human vaccines for infectious diseases.
Keyword:
human vaccine
infectious diseases
humanized mice
HIV-1
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.4
论文数:
1.0W
被引数:
2.6W
机构
引用论文
Inadequate T follicular cell help impairs B cell immunity during HIV infection.png)
NATURE MEDICINE
OAAI
NATURE MEDICINEIF50
OAAI分享收藏Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cellsNATURE IMMUNOLOGY
NATURE IMMUNOLOGYIF27.6
PREAI
分享收藏Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 InfectionVIRUSES-BASELOAAI
VIRUSES-BASELIF3.5
OAAI分享收藏Recurrent diarrhoea and weight loss associated with cessation of smoking in a patient with undiagnosed coeliac diseaseGutOAAI
GutIF0
OAAI分享收藏Design and immune characterization of a novel Neisseria gonorrhoeae DNA vaccine using bacterial ghosts as vector and adjuvantVaccine
VaccineIF0
PREAI
分享收藏
查看更多内容