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Aggressive Metastasis With Silent PET/CT: A Lesson From Well-differentiated Splenic Angiosarcoma

delete2026-04-01
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Xie, Miaomiao MM *
Z
Zhu, Hongchao MM *
L
Liu, Haiyan MM†
S
Sun, Rui MM‡
W
Weijing Tao *
DOI：10.1097/RLU.0000000000006391delete
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Abstract

Abstract

En 中文
Primary splenic angiosarcoma is a rare, aggressive malignancy carrying a poor prognosis. A 65-year-old woman with a pathologically confirmed well-differentiated splenic angiosarcoma developed liver metastases 5 months into follow-up. Subsequent 18F-FDG and 68Ga-FAPI PET/CT imaging revealed a “dual-negative” pattern, demonstrating no significant radiotracer uptake in the metastatic liver lesions. Despite well-differentiated histology, the tumor showed rapid progression, confirming aggressive behavior in well-differentiated angiosarcoma. The high-grade splenic angiosarcoma demonstrated negative findings on dual-tracer PET/CT, underscoring that vigilance and comprehensive multimodal evaluation are crucial for such occult malignancies.
Keywords:
well-differentiated splenic angiosarcoma
liver metastasis
18F-FDG
68Ga-FAPI
PET/CT

Journal

Clinical Nuclear Medicine cover
Clinical Nuclear Medicine
IF:
9.6
Papers:
1.1W
Citations:
6.9K

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