Aging microglia

Ignazio Antignano

doi:10.1007/s00018-023-04775-y

2023-04-21

DOI：10.1007/s00018-023-04775-y

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摘要

En 中文

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.

Keyword:

Microglia

Aging

Neuroinflammation

RNAseq

Human microglia

Senescence

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Cellular and Molecular Life Sciences

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6.2

论文数:

9.4K

被引数:

4.6W

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Helmholtz Association

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1.1K

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