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Alleviating role of taurine against tartrazine-induced hepatotoxicity in albino rat: Biochemical, histopathological, immunohistochemical, and gene expression assessments

delete2026-05-06
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PRE
AI
S
Samar Mortada Mahmoud *
R
Reham Abdel-Kareem
S
Sara F. Saadawy
H
Heba H. Mahboub *
A
Abdelfattah M. Abdelfattah
A
Amira Hamed Mohamed Soliman
DOI：10.1016/j.tice.2026.103570delete
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Abstract

Abstract

En 中文
• Tartrazine, a synthetic azo dye, poses potential health risks due to its hepatotoxic effects. • Taurine confers promising hepatoprotective effects against tartrazine with its antioxidant effects. • Taurine upregulates SIRT-1, a key protective molecule. • Taurine downregulates profibrotic and inflammatory markers including TGF β1, α-SMA, and HMGB-1/TNF-α signalling.
Keywords:
taurine
tartrazine
hepatotoxicity
SIRT-1
TGF β1

Journal

Tissue and Cell cover
Tissue and Cell
IF:
2.5
Papers:
867
Citations:
4.1K

Organization

M
menoufia university
Scholars:
267
Papers: 147
Citations: 0
Z
Zagazig University
Scholars:
5.9K
Papers: 5.0K
Citations: 91
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