Allosteric Modulators: A Side Door

doi:10.1021/acs.jmedchem.5b01824

2015-12-08

PRE

Mary E. Abood *

DOI：10.1021/acs.jmedchem.5b01824

原文链接

原文求助

摘要

En 中文

Allosteric modulators of the cannabinoid CB1 receptor were first discovered in 2005. Since then, although both negative and positive allosteric modulators have been uncovered, many questions remain about their site(s) of action, as well as the basis of their signaling. The described covalent probe with improved potency and efficacy will facilitate these studies.

Keyword:

RECEPTOR 1 CB1

CANNABINOID RECEPTOR

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Journal of Medicinal Chemistry

IF:

6.8

论文数:

2.7W

被引数:

9.4W

机构

pennsylvania commonwealth system of higher education (pcshe)

学者数:

12.9W

论文数: 11.7W

被引数: 177

引用论文

Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials 减肥药利莫那班的疗效和安全性: 随机试验的荟萃分析

LANCET

IF88.5

2007-11-01

949

PREAI

Christensen, Robin; Kristensen, Pernelle Kruse; Bartels, Else Marie; Blidda, Henning; Astrup, Arne

Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2013-10-01

OAAI

Cawston, Erin E.; Redmond, William J.; Breen, Courtney M.; Grimsey, Natasha L.; Connor, Mark; Glass, Michelle

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-04-01

132

OAAI

Ahn, Kwang H.; Mahmoud, Mariam M.; Shim, Joong-Youn; Kendall, Debra A.

Allosteric modulation of the cannabinoid CB1 receptor

MOLECULAR PHARMACOLOGY

IF3

2005-11-01

403

OAAI

Price, MR; Baillie, GL; Thomas, A; Stevenson, LA; Easson, M; Goodwin, R; McLean, A; McIntosh, L; Goodwin, G; Walker, G; Westwood, P; Marrs, J; Thomson, F; Cowley, P; Christopoulos, A; Pertwee, RG; Ross, RA

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor

MOLECULAR PHARMACOLOGY

IF3

2015-08-01

127

OAAI

Khajehali, Elham; Malone, Daniel T.; Glass, Michelle; Sexton, Patrick M.; Christopoulos, Arthur; Leach, Katie

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-01-29

182

OAAI

Horswill, J. G.; Bali, U.; Shaaban, S.; Keily, J. F.; Jeevaratnam, P.; Babbs, A. J.; Reynet, C.; In, P. Wong Kai

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-11-28

OAAI

Kulkarni, Pushkar M.; Kulkarni, Abhijit R.; Korde, Anisha; Tichkule, Ritesh B.; Laprairie, Robert B.; Denovan-Wright, Eileen M.; Zhou, Han; Janero, David R.; Zvonok, Nikolai; Makriyannis, Alexandros; Cascio, Maria G.; Pertwee, Roger G.; Thakur, Ganesh A.

没有更多内容