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ALPK1 promotes cardiomyocyte hypertrophy by activating NF-κB/NLRP3 inflammasome-mediated pyroptosis

delete2026-04-28
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PRE
AI
X
Xiaomi Zhuang
S
Shuai Han
Z
Zeyao Dong
W
Wenjie Pei
J
Jing Li
H
Haoxuan Sun
M
Mingyu Liu *
J
Jing Lu *
DOI：10.1016/j.yexcr.2026.115048delete
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Abstract

Abstract

En 中文
• ALPK1 is significantly upregulated in cardiac hypertrophy. • ALPK1 knockdown effectively suppresses Ang Ⅱ-induced NF-κB/NLRP3 inflammasome-mediated cardiomyocyte pyroptosis and hypertrophy. • ALPK1 over-expression promotes cardiomyocyte hypertrophy by activating NF-κB/NLRP3 inflammasome-mediated pyroptosis. • Targeting ALPK1 may provide new therapeutic strategies for cardiac hypertrophy.
Keywords:
ALPK1
cardiomyocyte hypertrophy
NF-κB/NLRP3 inflammasome
pyroptosis
therapeutic strategies

Journal

Experimental Cell Research cover
Experimental Cell Research
IF:
3.5
Papers:
1.1W
Citations:
2.0W

Organization

H
Harbin Medical University
Scholars:
2.9W
Papers: 1.3W
Citations: 1.6W
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