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Alteration of Colonic Circadian Rhythm by Gut Microbiota Dysbiosis and SCFA Reduction Links Chronic Stress-Induced Depressive-Like Behavior
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DOI：10.1016/j.psyneuen.2026.107869.png)
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Abstract
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• Multi-omics reveal a gut-to-brain pathway linking chronic stress to depressive-like behaviors. • Stress-induced gut dysbiosis and SCFA reduction correlate with colonic circadian clock alteration. • Altered colonic clock links to impaired intestinal barrier and elevated systemic inflammation. • Hippocampal neuroinflammation and synaptic gene changes coincide with this peripheral pathology.
Keywords:
gut microbiota dysbiosis
circadian rhythm
short-chain fatty acids
depressive-like behavior
neuroinflammation
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