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Altered assembly paths mitigate interference among paralogous complexes
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DOI：10.1038/s41467-024-51286-w.png)
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摘要
En 中文
Protein complexes are fundamental to all cellular processes, so understanding their evolutionary history and assembly processes is important. Gene duplication followed by divergence is considered a primary mechanism for diversifying protein complexes. Nonetheless, to what extent assembly of present-day paralogous complexes has been constrained by their long evolutionary pathways and how cross-complex interference is avoided remain unanswered questions. Subunits of protein complexes are often stabilized upon complex formation, whereas unincorporated subunits are degraded. How such cooperative stability influences protein complex assembly also remains unclear. Here, we demonstrate that subcomplexes determined by cooperative stabilization interactions serve as building blocks for protein complex assembly. We further develop a protein stability-guided method to compare the assembly processes of paralogous complexes in cellulo. Our findings support that oligomeric state and the structural organization of paralogous complexes can be maintained even if their assembly processes are rearranged. Our results indicate that divergent assembly processes by paralogous complexes not only enable the complexes to evolve new functions, but also reinforce their segregation by establishing incompatibility against deleterious hybrid assemblies.
Keyword:
COP9 SIGNALOSOME
QUALITY-CONTROL
STRUCTURAL INSIGHTS
SUBUNIT INTERACTION
PCI COMPLEXES
FACTOR EIF3
PROTEASOME
INITIATION
ARCHITECTURE
EXPRESSION
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期刊
IF:
15.7
论文数:
9.4W
被引数:
91.2W
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引用论文
PCI complexes: pretty complex interactions in diverse signaling pathways.png)
TRENDS IN PLANT SCIENCE
TRENDS IN PLANT SCIENCEIF20.8
PREAI
分享收藏MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger DatasetsMEGA7: 更大数据集的分子进化遗传学分析版本7.0OAAI
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