Amygdalin delivery via a hybrid hyaluronic acid–chitosan/carbon–metal oxide nanocomposite: In silico and in vivo anticancer evaluation in chemically induced squamous cell carcinoma mouse model

Sarah Ibrahim Baghdady

doi:10.1016/j.oraloncology.2026.108073

Amygdalin delivery via a hybrid hyaluronic acid–chitosan/carbon–metal oxide nanocomposite: In silico and in vivo anticancer evaluation in chemically induced squamous cell carcinoma mouse model

2026-07-07

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AI

S

Sarah Ibrahim Baghdady *

A

Abeer Salama

S

Sally A. Sabra *

A

Abdulrahman M. Saleh

E

Elbadawy A. Kamoun

S

Seham A. Hanafy

DOI：10.1016/j.oraloncology.2026.108073

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• A pH-responsive, CD44-targeted nanocomposite can afford controlled delivery of amygdalin. • The nanocomposite modulated the critical signaling pathways involved in tumor progression. • The prepared nanocomposite reduced the toxicity of amygdalin.

Amygdalin delivery via a hybrid hyaluronic acid–chitosan/carbon–metal oxide nanocomposite: In silico and in vivo anticancer evaluation in chemically induced squamous cell carcinoma mouse model

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