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An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials
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DOI：10.1016/j.pbiomolbio.2014.07.012.png)
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Abstract
En 中文
We developed and validated a new optical mapping system for quantification of electrical activation and repolarisation in murine atria. The system makes use of a novel 2nd generation complementary metaloxide-semiconductor (CMOS) camera with deliberate oversampling to allow both assessment of electrical activation with high spatial and temporal resolution (128 x 2048 pixels) and reliable assessment of atrial murine repolarisation using post-processing of signals. Optical recordings were taken from isolated, superfused and electrically stimulated murine left atria. The system reliably describes activation sequences, identifies areas of functional block, and allows quantification of conduction velocities and vectors. Furthermore, the system records murine atrial action potentials with comparable duration to both monophasic and transmembrane action potentials in murine atria. (C) 2014 The Authors. Published by Elsevier Ltd.
Keywords:
Optical mapping
Murine model
Isolated atrium
Conduction velocity
Atrial action potential duration
Atrial fibrillation
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