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An integrin α3β1-CSTF3 signaling axis regulates alternative polyadenylation of Mmp9 mRNA
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DOI：10.1016/j.matbio.2026.01.003.png)
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Abstract
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• α3β1-MEK/ERK regulates alternative polyadenylation of the Mmp9 gene during tissue remodeling. • α3β1-MEK/ERK induces cleavage stimulation factor CSTF3, a regulator of alternative polyadenylation. • DaPars2 analysis reveals that α3β1 regulates genome-wide alternative polyadenylation. • A novel α3β1-MEK/ERK-CSTF3 axis controls post-transcriptional gene regulation.
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