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An iterative neural processing sequence orchestrates feeding
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DOI：10.1016/j.neuron.2023.02.025.png)
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摘要
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Feeding requires sophisticated orchestration of neural processes to satiate appetite in natural, capricious settings. However, the complementary roles of discrete neural populations in orchestrating distinct behav-iors and motivations throughout the feeding process are largely unknown. Here, we delineate the behavioral repertoire of mice by developing a machine-learning-assisted behavior tracking system and show that feeding is fragmented and divergent motivations for food consumption or environment exploration compete throughout the feeding process. An iterative activation sequence of agouti-related peptide (AgRP)-express-ing neurons in arcuate (ARC) nucleus, GABAergic neurons in the lateral hypothalamus (LH), and in dorsal raphe (DR) orchestrate the preparation, initiation, and maintenance of feeding segments, respectively, via the resolution of motivational conflicts. The iterative neural processing sequence underlying the competition of divergent motivations further suggests a general rule for optimizing goal-directed behaviors.
Keyword:
VENTRAL TEGMENTAL AREA
LATERAL HYPOTHALAMUS
GABAERGIC PROJECTIONS
CIRCUIT
NEURONS
BEHAVIORS
HUNGER
SUPPRESSION
NUCLEUS
REWARD
期刊
IF:
15
论文数:
1.4W
被引数:
9.9W
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